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動物資源技術センター

資源開発室

我々は、過剰排卵誘起、体外受精、胚移植、胚/配偶子の凍結保存などの生殖工学技術を駆使することで、遺伝子改変マウスの作製やモデルマウスの系統管理を行っています。さらに効率的な遺伝子改変技術、凍結保存技術・系統管理の開発・改良に取り組み、再現性の高い、迅速、安定な実験動物の提供することで、生命科学やバイオメディカル領域へ貢献しています。

【業務内容】

  1. 卵子、精子、胚の凍結保存、および提供
  2. 微生物クリーニング(SPF化、無菌動物化)
  3. 遺伝子改変動物の作製
  4. スピードコンジェニック等の系統育成
  5. 繁殖不全動物の維持、生産、保存
  6. 生殖工学技術に関する技術開発改良
  7. 各種生殖工学技術を用いた受託試験・共同研究
  8. 生殖工学技術に関する教育・研修
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マウス資源集計
※代表的な研究論文
  1. An HTLV-1-Infected Humanized Mouse Model Expressing HLA-A*02:01 Demonstrates Effective CTL-Mediated Suppression of HTLV-1.
    Nakajima S, Goto M, Lee SI, Odaka T, Hino M, Tezuka K, Takenouchi N, Ueno T, Admadiani FR, Takahashi R, Hamaguchi I, Takahashi T, Ito M, Okuma K.
    Viruses. 2025 Sep 16;17(9):1249.
  2. Generation of a Severe Hemophilia A Humanized Mouse Model Capable of Inducing an Anti-FVIII Immune Response.
    Oda A, Furukawa S, Kitabatake M, Ouji-Sageshima N, Ito T, Takahashi R, Kawamura T, Nakajima Y, Shimonishi N, Ogiwara K, Shima M, Nogami K.
    Thromb Haemost. 2025 May;125(5):435-446.
  3. A Novel Immunodeficient Hyperglycemic Mouse Carrying the Ins1 Akita Mutation for Xenogeneic Islet Cell Transplantation.
    Nakano K, Goto M, Fukuda S, Yanobu-Takanashi R, Yabe SG, Shimizu Y, Sakuma T, Yamamoto T, Shimoda M, Okochi H, Takahashi R, Okamura T.
    Transplantation. 2025 Feb 1;109(2):e81-e91.
  4. Improved ion detection sensitivity in mass spectrometry imaging using tapping‑mode scanning probe electrospray ionization to visualize localized lipids in mouse testes.
    Otsuka Y, Okada M, Hashidate‑Yoshida T, Nagata K, Yamada M, Goto M, Sun M, Shindou H, Toyoda M.
    Anal Bioanal Chem. 2025 Jan;417(2):275-286.
  5. Human dendritic cell differentiation in hematopoietic stem cell-transplanted NOG hFLT3L Tg/mFlt3 KO humanized mice.
    Mu Y, Ohno Y, Mochizuki M, Kawai K, Goto M, Ogura T, Takahashi R, Ito M, Ito R.
    Immunol Lett. 2024 Dec:270:106943.
  6. Genome editing using type I-E CRISPR-Cas3 in mice and rat zygotes.
    Yoshimi K, Kuno A, Yamauchi U, Hattori K, Taniguchi H, Mikamo K, Iida R, Ishida S, Goto M, Takeshita K, Ito R, Takahashi R, Takahashi S, Mashimo T.
    Cell Rep Methods. 2024 Aug 19;4(8):100833.
  7. Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice.
    Ito R, Ohno Y, Mu Y, Ka Y, Ito S, Emi-Sugie M, Mochizuki M, Kawai K, Goto M, Ogura T, Takahashi R, Niwa A, Nakahata T, Ito M.
    Stem Cell Res Ther. 2024 Jun 21;15(1):182.
  8. Dietary omega-3 fatty acid does not improve male infertility caused by lysophospholipid acyltransferase 3 (LPLAT3/AGPAT3) deficiency.
    Nagata K, Kakizaki Y, Yanagida K, Arai T, Nakano K, Hamano F, Goto M, Okamura T, Shimizu T, Shindou H.
    Biochem Biophys Res Commun. 2023 Jun 30:663:179-185.
  9. A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy.
    Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H.
    Gene Ther. 2023 Apr;30(3-4):288-296.
  10. Efficient differentiation of human neutrophils with recapitulation of emergency granulopoiesis in human G-CSF knockin humanized mice.
    Ito R, Katano I, Kwok IWH, Ng LG, Ida-Tanaka M, Ohno Y, Mu Y, Morita H, Nishinaka E, Nishime C, Mochizuki M, Kawai K, Chien TH, Yunqian Z, Yiping F, Hua LH, Celhar T, Yen Chan JK, Takahashi T, Goto M, Ogura T, Takahash R, Ito M.
    Cell Rep. 2022 Dec 20;41(12):111841.
  11. Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism.
    Uehara S, Iida Y, Ida-Tanaka M, Goto M, Kawai K, Yamamoto M, Higuchi Y, Ito S, Takahashi R, Kamimura H, Ito M, Yamazaki H, Oshimura M, Kazuki Y, Suemizu H.
    Sci Rep. 2022 Sep 1;12(1):14907.
  12. Establishment of an integrated automated embryonic manipulation system for producing genetically modified mice.
    Eto T, Ueda H, Ito R, Takahashi T, Watanabe T, Goto M, Sotomaru Y, Tanaka N, Takahashi R.
    Sci Rep. 2021 Jun 3;11(1):11770.
  13. Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells.
    Wang B, Iriguchi S, Waseda M, Ueda N, Ueda T, Xu H, Minagawa A, Ishikawa A, Yano H, Ishi T, Ito R, Goto M, Takahashi R, Uemura Y, Hotta A, Kaneko S.
    Nature Biomedical Engineering. 2021 May;5(5):429-440.
  14. DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions.
    Sato K, Yamashita-Kanemaru Y, Abe F, Murata R, Nakamura-Shinya Y, Kanemaru K, Muratani M, Veillette A, Goto M, Ito M, Shibuya A, Shibuya K.
    Proc Natl Acad Sci USA. 2021 May 25;118(21):e2021309118.
  15. Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells.
    Suzuki　M, Sujino T, Chiba S, Harada Y, Goto M, Takahashi R, Mita M, Hamase K, Kanai T, Ito M, Waldor MK, Yasui M, Sasabe J.
    Sci Adv. 2021 Mar 3;7(10):eabd6480.
  16. Efficient production of immunodeficient non-obese diabetic/Shi-scid IL2rcnull mice via the superovulation technique using inhibin antiserum and gonadotropin.
    Goto M, Takeo T, Takahashi R, Nakagata N.
    Laboratory Animals. 2021 Feb;55(1):13-20.
  17. Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model.
    Abe Y, Ikegawa N, Yoshida K, Muramatsu K, Hattori S, Kawai K, Murakami M, Tanaka T, Goda W, Goto M, Yamamoto T, Hashimoto T, Yamada K, Shibata T, Misawa H, Mimura M, Tanaka KF, Miyakawa T, Iwatsubo T, Hata JI, Niikura T, Yasui M.　
    Acta Neuropathol Commun. 2020 May 12;8(1):67.
  18. Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain.
    Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, Ihara Y, Misonou H, Miyasaka T.
    J Neurosci. 2019 Aug 21;39(34):6781-6797.
  19. Development of blastocyst complementation technology without contributions to gametes and the brain.
    Hashimoto H, Eto T, Yamamoto M, Yagoto M, Goto M, Kagawa T, Kojima K, Kawai K, Akimoto T, Takahashi R.
    Exp Anim. 2019 Aug 14;68(3):361-370.
  20. Novel reporter and deleter mouse strains generated using VCre/VloxP and SCre/SloxP systems, and their system specificity in mice.　
    Yoshimura Y, Ida-Tanaka M, Hiramaki T, Goto M, Kamisako T, Eto T, Yagoto M, Kawai K, Takahashi T, Nakayama M, Ito M.　
    Transgenic Res. 2018 Apr;27(2):193-201.
  21. Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.　
    Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M.　
    Stem Cell Reports. 2018 Mar 13;10(3):1059-1074.

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